The summer school will focus on the effective exploitation of High Performance Computing (HPC) systems. Traditional parallel programming approaches, based on the message-passing paradigm, are no longer sufficient to fulfil this task, and innovative solutions need to be addressed. During the two weeks of the school a number of such solutions will be presented. The MPI, OpenMP, CUDA, OpenACC programming models will be introduced, together with scientific libraries and efficient I/O solutions. Their effective combined usage, in order to achieve an ideal exploitation of large hybrid architectures, will be discussed and experimented with extensive practical and exercise lab sessions to help clarify and consolidate the theoretical material presented. The Summer School preferentially addresses undergraduate students and Ph.D. students. The school will take place in July 2018 at Hotel Serpiano, a beautiful location in Ticino, Switzerland.