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Mathematical cardiac physiology


The course covers mathematical and numerical aspects of cardiac physiology. The course is composed by 4 lectures in total. The first lecture will focus on electrophysiology. We will present the bidomain model and its derivation from basic principles, and excitation waves solutions associated to it. We will also cover simplified models such as the monodomain and eikonal models. The second lecture is on the numerical discretization and computational aspects for the bidomain model. The third lecture is devoted to cardiac mechanics and the electro-mechanic and mechano-electric coupling. Finally, the last lecture will focus on applications of clinical interest, including ECG simulation, cardiac resynchronization therapy and atrial fibrillation.

Further details are available here.



  • Keener J., Sneyd J., Mathematical Physiology. Cambridge university press, 2009
  • Colli Franzone et al., Mathematical Cardiac Electrophysiology. Springer, 2014
  • Katz, A.M., Physiology of the Heart, Lippincott W&W, 2010
  • Smith, N.P. et al., Multiscale computational modelling of the heart, Acta Numerica 13, (2004)



Pezzuto S.

Course director

Additional information

Academic year
English, German
PhD programme of the Faculty of Informatics, PhD course, Lecture, 2nd year

PhD programme of the Faculty of Informatics, PhD course, Lecture, 1st year