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Francesco Bertoni


Prof. Francesco Bertoni is the head of the Lymphoma Genomics group at Institute of Onolcogy Research in Bellinzona, Switzerland, the Institute deputy director, and Adjunct Professor at the Università della Svizzera italiana (USI).His research topics are the development of new anti-lymphoma compounds and lymphoma genomics. Bertoni obtained a Medical Degree magna cum laude (1994) and the Medical Oncology Specialty (1998) from the State University of Milan (Italy). During his career he has worked in Milan (Ospedale Maggiore Policlinico and “Mario Negri” Institute of Pharmacological Research), London (Institute of Child Health and The Barts and The London) and in Ticino (Servizio Oncologico Cantonale). Since April 2003, he has been leading his group is in Bellinzona. Since 2019 he is the President of the Local Organizing Committee of the International Conference on Malignant Lymphoma (ICML). Since January 2009 he is the Editor-in-Chief of Hematological Oncology. Bertoni has supervised several Master and PhD students. Bertoni actively participates to Swiss Cancer Research Group (SAKK), in which he is the President of the Project Group Lymphoma and member of the Project Group Developmental Therapeutics. Prof. Bertoni is the author or co-author of over 200 original papers, over 50 editorials or invited reviews, 20 book sections, one edited book and several abstracts at national and international meetings.


On-going projects

-      Development of novel anti-lymphoma agents

-    GPCRs of the olfactory receptors family as potential therapeutic targets against lymphoma cells

-      An integrated approach to identify the mechanism of resistance to copanlisib and venetoclax in marginal zone lymphoma

-      Transcriptome analysis to improve the outcome prediction and to identify novel therapeutics targets in follicular lymphoma patients

-      Genetic screening of enhancer RNAs to understand their causative biological role in refractory diffuse large B cell lymphoma

-      Development of a microfluidic platform for real-time detection of SARS-CoV-2 virus based on multifunctional silica membrane biosensors

-      Characterization of specific enhancer RNAs involved in ibrutinib resistance mechanism in marginal zone lymphoma

-      Ultra-conserved long non-coding RNAs in B-cell lymphoma

-      Finding a way to by-pass the resistance to PI3K inhibitors in marginal zone lymphomas 

-      CA18238 - European transdisciplinary networking platform for marine biotechnology

-      Targeted agents in splenic marginal zone lymphoma: mechanisms of resistance and new combinations

Competence areas