Search for contacts, projects,
courses and publications

EHVA - European HIV Vaccine Alliance (EHVA): a EU platform for the discovery andevaluation of novel prophylactic and therapeutic vaccine candidates

People

 

Lanzavecchia A.

(Responsible)

Abstract

Despite enormous progress in the prevention and treatment of HIV/AIDS, the global response cannot keep pace: 35 million people are living with HIV worldwide with ca 6,000 new infections each day. Numerous HIV prevention strategies (such as PrEP and PEP), though proven successful, are difficult to sustain long-term. A vaccine still represents the most effective tool in the combat against HIV from a public health perspective. To date, many prophylactic and therapeutic vaccine concepts have been developed and several efficacy trials have been conducted but with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at the early stage of vaccine development to mitigate the risks of failure.

EHVA APPROACH

To address these complex and challenging scientific issues, EHVA aims to develop a Multidisciplinary Vaccine Platform through a global and innovative alliance notably:

• Multidisciplinary expertise from vaccine discovery, to immune monitoring to clinical development

• State-of-the-art innovative technologies to profile immune responses and virus reservoir

• Access to large cohort studies bringing together top European clinical centres in the fields of  prophylactic and therapeutic vaccines

• Access to a panel of experimental HIV vaccines under clinical development as benchmark

• Liaison with African leading scientists/programs fostering future testing of EHVA vaccines in Sub-Saharan Africa

• Engagement of industrial expertise for downstream vaccine development

EHVA OBJECTIVES

EHVA plans to develop and implement:

Discovery Platform with the goal of generating novel vaccine candidates inducing potent neutralizing and non-neutralizing antibody responses and Tcell responses

Immune Profiling Platform with the goal of ranking novel and existing (benchmark) vaccine candidates on the basis of the immune profile

Data Management/Integration/Down-Selection Platform, with the goal of  providing statistical tools for the analysis and interpretation of complex data and algorithms for the efficient selection of vaccines

Clinical Trials Platform with the goal of accelerating the clinical development of novel vaccines and the early prediction of vaccine failure.

Additional information

Acronym
EHVA
Start date
01.01.2016
End date
31.12.2020
Duration
60 Months
Funding sources
Confederazione svizzera
Status
Ended
Category
European and International Programmes / Horizon 2020