Infections or vaccines associated with Finkelstein-Seidlmayer vasculitis
systematic review
Additional information
Authors
Bronz G.,
Betti C.,
Rinoldi P. O.,
Kottanattu L.,
Bianchetti M.,
Consolascio D.,
Bergmann M.,
Milani G.,
Terziroli Beretta-Piccoli B.,
Lava S. A.
Type
Journal Article
Year
2022
Language
English
Abstract
Finkelstein-Seidlmayer vasculitis, also referred to as acute hemorrhagic edema of young children, is a rare small-vessel leukocytoclastic vasculitis. This condition is skin-limited, mainly affects infants up to 2 years of age and spontaneously remits. It has been suggested that an infection or a vaccine precede (by ≤ 14 days) this vasculitis. To better understand the interplay between infections or vaccines and Finkelstein-Seidlmayer vasculitis, we utilized the data contained in the Acute Hemorrhagic Edema BIbliographic Database AHEBID. The database, initiated in 2019, is being regularly updated, encompasses the entire original literature on Finkelstein-Seidlmayer vasculitis published after the original description and is attainable on request. The possible existence of an infectious or a vaccine precursor was addressed in 447 cases. Most cases were preceded by an infection (N = 384; 86%), by a vaccination (N = 20; 4.4%), or both an infection and a vaccination (N = 17; 3.8%). No precursor was reported in the remaining cases (N = 26; 5.8%). Two distinct infections preceded the onset of the vasculitis in 11 of the 381 cases with infection-associated Finkelstein-Seidlmayer vasculitis. The following infectious precursors were reported: upper respiratory tract infection (N = 292); acute gastroenteritis (N = 40); a benign febrile infection (N = 36); lower respiratory tract infection (N = 22); further infections (N = 8). The temporal relationship between the infectious precursor and the onset of the skin eruption was detailed in 336 cases: 54 cases developed before resolution and 282 after resolution of the infection. In conclusion, most cases of Finkelstein-Seidlmayer vasculitis are preceded by an infection. In a minority of cases, this skin vasculitis develops before resolution of the infection. In most cases, however, this vasculitis develops after resolution of the infection. More rarely, this vasculitis is preceded by a vaccination.
Keywords
Acute hemorrhagic edema of young children, Cockade purpura with edema , Finkelstein-Seidlmayer vasculitis, Infection, Precursor, Small-vessel leukocytoclastic vasculitis, Vaccination
Journal
Clinical reviews in allergy and immunology
Volume
63
Pages (or article number)
490–498
Diffusion
License
CC BY
Visibility
Public
Status open access
Hybrid
