JC polyomavirus nephropathy
a rare complication late after kidney transplantation
Informazioni aggiuntive
Autori
Scotti Gerber J.,
De Marchi S.,
Gaspert A.,
Fehr T.,
Cippà P.
Tipo
Articolo pubblicato in rivista scientifica
Anno
2024
Lingua
Inglese
Sommario
Introduction: JC-polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of allograft dysfunction with only a few cases described in the literature. Case Presentation: we present 2 cases of JC-PVAN, both of which occurred >5 years after kidney transplantation. In both cases, transplant biopsies were performed because of worsening of kidney function. We found tubulitis and interstitial inflammation; immunohistochemistry was positive for SV40, but BK virus was not detected. The presence of JC virus confirmed the diagnosis of JC-PVAN. Immunosuppressive therapy was adopted, but in both cases graft function progressively deteriorated. Conclusions: our cases show that JC-PVAN, although much rarer than BK-PVAN, should be considered a possible cause of graft dysfunction even years after transplantation. Complete diagnostic workup, including kidney biopsy, is crucial for correct diagnosis and treatment.
Parole chiave
Kidney transplantation, Infection, JC virus, Polyoma nephropathy, BK virus
Periodico
Case reports in nephrology and dialysis
Volume
14
Numero ( Mese )
1
Pagine (o numero dell’articolo)
148-157
Diffusione
Licenza
CC BY-NC
Visibilità
Pubblico
Status open access
Hybrid
