Autoimmune markers and vascular immune deposits in Finkelstein-Seidlmayer vasculitis
systematic literature review
Informazioni aggiuntive
Autori
Bronz G.,
Jvan G.,
Passi A. G.,
Rizzi M.,
Bergmann M.,
Milani G.,
Lava S. A. G.,
Bianchetti M.,
Terziroli Beretta-Piccoli B.,
Vanoni F.
Tipo
Articolo pubblicato in rivista scientifica
Anno
2023
Lingua
Inglese
Sommario
Finkelstein-Seidlmayer vasculitis, also called acute hemorrhagic edema of young children or infantile immunoglobulin A vasculitis, is habitually a benign skin-limited small vessel leukocytoclastic vasculitis that mainly affects infants 24 months or less of age. Since this disease is commonly triggered by an infection, an immune-mediated origin has been postulated. To better appreciate the possible underlying immune mechanism of this vasculitis, we addressed circulating autoimmune markers and vascular immune deposits in patients contained in the Acute Hemorrhagic Edema BIbliographic Database, which incorporates all original reports on Finkelstein-Seidlmayer vasculitis. A test for at least one circulating autoimmune marker or a vascular immune deposit was performed in 243 cases. Subunits of complement system C4 resulted pathologically reduced in 4.7% and C3 in 1.4%, rheumatoid factor was detected in 6.1%, and antinuclear antibodies in 1.9% of cases. Antineutrophil cytoplasmic antibodies were never demonstrated. Immunofluorescence studies were performed on 125 skin biopsy specimens and resulted positive for complement subunits in 46%, fibrinogen in 45%, immunoglobulin A in 25%, immunoglobulin M in 24%, immunoglobulin G in 13%, and immunoglobulin E in 4.2% of cases. Infants testing positive for vascular immunoglobulin A deposits did not present a higher prevalence of systemic involvement or recurrences, nor a longer disease duration. In conclusion, we detected a very low prevalence of circulating autoimmune marker positivity in Finkelstein-Seidlmayer patients. Available immunofluorescence data support the notion that immune factors play a relevant role in this vasculitis. Furthermore, vascular immunoglobulin A deposits seem not to play a crucial role in this disease.
Parole chiave
Finkelstein-Seidlmayer vasculitis , Acute Hemorrhagic Edema Bibliographic Database, Rheumatoid factor, Anti-nuclear antibodies, Immunoglobulin A
Periodico
Journal of autoimmunity
Volume
136
Pagine (o numero dell’articolo)
103002
Diffusione
Licenza
CC BY
Visibilità
Pubblico
Status open access
Hybrid
