Neuropathies related to hepatitis E virus infection
a prospective, matched case–control study
Informazioni aggiuntive
Autori
Ripellino P.,
Lascano A. M.,
Scheidegger O.,
Schilg-Hafer L.,
Schreiner B.,
Tsouni P.,
Vicino A.,
Peyer A. K.,
Humm A. M.,
Décard B. F.,
Pianezzi E.,
Zezza G.,
Sparasci D.,
Hundsberger T.,
Dietmann A.,
Jung H.,
Kuntzer T.,
Wilder-Smith E.,
Martinetti-Lucchini G.,
Petrini O.,
Fontana S.,
Gowland P.,
Niederhauser C.,
Gobbi C.
Tipo
Articolo pubblicato in rivista scientifica
Anno
2023
Lingua
Inglese
Sommario
Background: acute hepatitis E virus (HEV) infection has recently emerged as a potential trigger for acute dysimmune neuropathies, but prospective controlled studies are lacking. Aims: to compare the frequency of concomitant acute HEV infection in patients with neuralgic amyotrophy (NA), Guillain–Barré syndrome (GBS), and Bell's palsy with a matched control population. Methods: Swiss multicenter, prospective, observational, matched case–control study over 3 years (September 2019–October 2022). Neurological cases with NA, GBS, or Bell's palsy were recruited within 1 month of disease onset. Healthy controls were matched for age, sex, geographical location, and timing of blood collection. Diagnostic criteria for acute hepatitis E were reactive serum anti-HEV IgM and IgG assays (ELISA test) and/or HEV RNA detection in serum by real-time polymerase chain reaction (RT-PCR). RT-PCR was performed on sera to confirm IgM positivity. Results: we included 180 patients (59 GBS, 51 NA, 70 Bell's palsy cases) and corresponding matched controls (blood donors) with median age 51 years for both groups and equal gender distribution. Six IgM+ cases were detected in the NA, two in the GBS, and none in the Bell's palsy group. Two controls were anti-HEV IgM-positive. At disease onset, most cases with acute HEV infection had increased liver enzymes. A moderate association (p = 0.027, Fisher's exact test; Cramér's V = −0.25) was observed only between acute HEV infection and NA. Conclusion: this prospective observational study suggests an association between concomitant acute HEV infection and NA, but not with GBS or Bell's palsy.
Parole chiave
Bell's palsy, Guillain–Barré syndrome, Hepatitis E, Neuralgic amyotrophy, Parsonage–Turner syndrome
Periodico
European journal of neurology
Volume
31
Numero ( Mese )
1
Diffusione
Licenza
CC BY-NC
Visibilità
Pubblico
Status open access
Hybrid
