Institute for Research in Biomedicine (IRB)
Projects
In progress (29)
- Monticelli S. (2024) Bridging T Cell Receptor and Integrin Signaling Pathways with SKAP2 - Functional Insights and Biochemical Characterization
- Molinari M. (2024) ER-phagy: the lysosomal control of endoplasmic reticulum homeostasis
- Cecchinato V. (2024) NATURAL AUTOANTIBODIES TARGETING CHEMOKINES IN HIV-1 INFECTION AND PATHOGENESIS
- Cavalli A. (2024) 222762 - AntibodyGPT: Language Modeling for fast ex novo Monoclonal Antibody Generation and Evolution
- Mangani D. (2024) Modulation of P2X receptor signaling in intestinal microbiota/host cross talk to improve the efficacy of immunotherapy in solid tumors.
- Geiger R. (2024) IMMERGE - Storming Immune Monogenic Conditions through Multiomic and Gene Editing Approaches
- Cassotta A. (2023) Dynamics of immune response after myocardial infarction
- Virgilio T. (2023) Reprogramming Metastasis Infiltrating NK (MINKs) into tumor killers
- Sgrignani J. (2023) Restoring PTEN function by small molecule induced deubiquitination
- Guarda G. (2023) Dimension++ - Conformational changes in NLRC5 function
- Geiger R. (2023) TOP-GUT - Training for Organoids modelling Physiology and Pathology in the human gastrointestinal tract
- Molinari M. (2023) Protein quality control and degradation from the endoplasmic reticulum
- Varani L. (2023) Multispecific antibodies against infectious diseases
- González F. S., Krause R., Pizzagalli D. U. (2023) RE2Vital - REuse and REproducibility of intraVITAL microscopy via open data practices in image-driven immunological research
- (2023) ModelArchive - Open Research Data (ORD) best practices for computational macromolecular models
- Cejka P. (2022) Regulation of the MutL-gamma (MLH1-MLH3) nuclease in DNA mismatch repair and meiosis
- Bertoni F. (2022) Protein-coupled receptors of the olfactory receptors’ family provide novel therapeutic opportunities against lymphoma cells
- Varani L. (2022) SARS-CoV-2: understanding the entry, multi-organ spread, and immune response in the context of vaccination and re-infection
- Geiger R. (2022) A human tumor model for preclinical immunotherapy trials
- González F. S. (2022) C-type lectin receptors and their implication in the innate response against respiratory pathogens
- Cejka P. (2022) BRCA INSIGHTS - Understanding the functions of the BRCA protein complexes in DNA break repair and in replication stress
- Monticelli S. (2022) Excellence Grant - Cell-intrinsic mechanisms modulating inflammatory responses in T lymphocytes
- Varani L. (2022) ISIDORe - Integrated Services for Infectious Disease Outbreak Research
- Monticelli S. (2022) Cell-intrinsic mechanisms modulating inflammatory responses in T-lymphocytes
- Cavalli A. (2022) KIAA1199 and hyaluronic acid signaling: a promising therapeutic approach for glomerular disease.
- Cejka P. (2021) First steps in DNA double-strand break repair: underlying mechanisms and regulation
- Guarda G. (2021) Understanding the connections between cellular metabolism, MHC class I regulation, and the immune response
- Robbiani D. (2021) Sources of genomic instability in B cell malignancy
- Geiger R. (2021) CRISPR - Activation and knockout screens to augment anti-tumor T cell responses
Completed (137)
- Uguccioni M. (2023) 221504 - 2ND INTERNATIONAL WORKSHOP ON ANKYLOSING SPONDYLITIS: TALES OF MOLECULES AND PATIENTS
- Varani L. (2023) Immunotherapy for Infectious disease (ITID) conference 2023
- Robbiani D. (2023) The human immune response to West Nile virus infection
- Geiger R., Catapano C., Cejka P., Sallusto F., Theurillat J. P. (2022) timsTOF Pro 2 for clinical proteomics
- Thelen M. (2022) 2022 Gordon Research Conference on: Chemotactic Cytokines
- Cavalli A., Robbiani D. (2022) Rational design of neutralising antibodies resilient to virus escape
- Robbiani D. (2021) Human antibodies to tick-borne flaviviruses
- Guarda G. (2021) Deciphering Mycregulation and funcion in NK cells
- González F. S., Virgilio T. (2021) Characterizazion of the Innate Immune Responses against SARS-CoV-2
- González F. S. (2021) Le molte facce del contagio
- Molinari M. (2021) Non-competitive pharmacologic chaperones developed through the Site-directed Enzyme Enhancement Therapy (SEE-Tx) technology for the treatment of rare genetic and neurodegenerative diseases
- Grassi F. (2020) Investigating the enhanced mucosal immune response against vaccines and protection against bacterial infections promoted by the ATPase Apyrase
- Uguccioni M. (2020) Development of an innovative therapy for ANCA- associated vasculitis (AAV)
- Thelen M. (2020) 2020 Gordon Research Conference on: Chemotactic Cytokines
- Monticelli S. (2020) RNA-binding proteins and control of mRNA metabolism in the regulation of adaptive immunity in humans
- Grassi F. (2020) Structure and function of secretory IgA repertoire in intestinal homeostasis
- Varani L., Robbiani D. (2020) ATAC - Antibody therapy against coronavirus (COVID-19)
- Grassi F. (2020) Intestinal ecosystem conditioning to improve the outcome of cancer immunotherapy with checkpoint inhibitors
- Sallusto F. (2020) New approaches to study T cell activation, differentiation and plasticity in humans
- González F. S., Krause R. (2019) IMMUNEMAP - Enabling data-driven immunological research by making two-photon intravital microscopy data FAIR
- Molinari M. (2019) CHAPERONE - Allosteric chaperones to treat rare lysosomal storage disorders
- Molinari M. (2019) Protein folding, quality control and degradation in the endoplasmic reticulum
- Guarda G. (2019) Deciphering the divergent roles of phosphatases in PD-1 and cytokine signaling
- Varani L. (2019) Characterization of antibody-antigen interactions in human pathogens
- Geiger R. (2019) The development of a platform to rapidly identify tumor antigene-specific T cells receptors for therapy
- Sallusto F. (2019) Lymphocyte T helper (Th) cell differentiation in patients with inborn errors of immunity to Mycobacterium and/or Candida species
- Geiger R. (2019) TIL-FIT - Increasing the fitness of tumor-infiltrating T cells for cellular immunotherapy
- Thelen M. (2018) Function of ACKR3 in immune cell trafficking in lymphoid organs
- Monticelli S. (2018) NCCR RNA& Disease - NCCR RNA & Disease: The role of RNA in disease mechanisms
- Monticelli S. (2018) Transcriptional control of human T lymphocyte pathogenic potential in autoimmunity
- González F. S. (2017) TANTUMorNEUVACCINE - Neutrophil subtypes: distinct cellular targets for therapeutic intervention
- Cejka P. (2017) Beyond DNA end resection: Role of homologous recombination in the maintenance of genome stability
- Lanzavecchia A. (2017) Antibody diversification by templated insertions: impact, mechanism and exploitation
- González F. S. (2017) Role of lymph node phagocytes in the regulation of the IgG-mediated suppression of the immune response to influenza vaccine
- Sallusto F. (2017) RT Cure - Rheuma Tolerance for Cure
- Uguccioni M. (2017) International Meeting “Ankylosing Spondylitis: Tales of Molecules and Patients”
- Grassi F. (2017) Role of ATP gated ionotropic P2X7 receptor in regulating adaptive mucosal immunity, host-microbiota mutualism
- Sallusto F. (2016) ZIKAlliance - A global alliance for Zika virus control and prevention
- Cejka P. (2016) HRMECH - Nucleases in homologous recombination: from basic principles to genome editing
- Sallusto F. (2016) Studies on T cell activation, differentiation and plasticity in humans
- Cavalli A. (2016) Identification of structural determinants of light chain amyloidosis
- Guarda G. (2016) T CELL-INTRINSIC ROLE OF PATTERN RECOGNITION RECEPTORS
- Montagner S. (2016) Epigenetic regulation of mast cell differentiation and function
- Varani L. (2016) Characterization of antibody-antigen interactions in human pathogens
- Lanzavecchia A. (2016) EHVA - European HIV Vaccine Alliance (EHVA): a EU platform for the discovery andevaluation of novel prophylactic and therapeutic vaccine candidates
- Molinari M. (2016) Protein folding, quality control and degradation in the endoplasmic reticulum
- Thelen M. (2015) Interplay of classical and atypical chemokine receptors in immune cell trafficking and dynamic microarchitecture of the secondary lymphoid organs
- Lanzavecchia A. (2015) BROADimmune - Structural, genetic and functional analyses of broadly neutralizing antibodies against human
- Cejka P. (2015) Repair of damaged DNA by homologous recombination and related pathways
- Thelen M. (2015) The Atypical Chemokine Receptor ACKR3: Function in vivo in Immune Responses and Coupling to Signal Transduction Pathways
- Varani L., Catapano C., Cavalli A., Lanzavecchia A., Thelen M., Uguccioni M. (2015) Acquisition of a 600MHz solution NMR spectrometer
- Lanzavecchia A. (2015) Analytic vaccinology
- Thelen M. (2015) First European Chemokine and Cell Migration Conference (ECMC2015)
- Grassi F. (2015) Systemic impact of purinergic P2X7 receptor activity at the interface between gut-associated lymphoid tissue and commensal microflora
- Monticelli S. (2015) DNA methylation landscape in mast cell differentiation and systemic mastocytosis
- Molinari M. (2014) ER-phagy mechanisms to maintain and restore endoplasmic reticulum homeostasis
- Sallusto F. (2014) UnmetMS - Unraveling the immune etiology of multiple sclerosis
- González F. S. (2014) A massively parallel space-time connected approach based on implicit active contour methods to track leukocytes observed by multiphoton intra vital and confocal microscopy
- González F. S. (2014) IMPORED - Intravital imaging of polymicrobial respiratory diseases
- Grassi F. (2013) System for on-line Monitoring of Human Metabolic Conditions in Critical patients
- Varani L. (2013) Mass Virus Typer: New Technology for Direct Virus Characterization
- Sallusto F. (2013) Studies on T cell activation, differentiation and plasticity in humans
- Monticelli S. (2013) Role of microRNAs in reactivation of encephalitogenic T cells
- Lanzavecchia A. (2013) Tuning of immune homeostasis and immune response by persistent viral infections
- González F. S. (2013) IRINVAC - Immune responses to influenza vaccine
- Grassi F. (2013) Innovative Enabling Micro-Nano-Bio-technologies for Implantable systems in molecular medicine and personalized therapy – Project prolongation
- Sallusto F. (2013) PREDICT - Dissecting the human T cell response to pathogens, allergens, and self-antigens
- Uguccioni M. (2013) Impact of Synergy-inducing Molecules on Chemokine Activities
- González F. S., Sallusto F., Thelen M. (2012) Acquisition of a 2-Photon microscope for intravital analysis
- Grassi F. (2012) TIROTAPS - Transient Receptor Potential Melastatin-like 7 (TRPM7) in Regualation of T cell subsets and Purinering Signaling
- Lanzavecchia A. (2012) Human B cells and plasma cells in health and diseases
- Thelen M. (2012) Conventional and atypical chemokine receptors: different mechanisms of function and common responses
- Lanzavecchia A. (2012) LINFOEPAB - CD4 T and B Lymphocytes in hepatitis B patients: role in acute and chronic infection
- Varani L. (2012) Antibody-antigen interactions in Dengue virus
- Grassi F. (2012) Purinergic control of adaptive immunity by P2X7 receptor
- Molinari M. (2012) Protein folding, quality control and degradation in the endoplasmic reticulum
- Lanzavecchia A. (2012) ABIRISK - Anti-Biopharma ceutical Immunization: Prediction and anlysis of clinical rlevance to minimize the risk
- Monticelli S. (2012) Analysis of novel molecular networks underlying mast cell development, function and disease: specific roles of CD25, NF-kB p50 and microRNAs
- Varani L. (2012) Antibodies against Dengue Virus: which ones are effective against this neglected disease and why? Searching for correlations between structural, dynamics and immunological properties of antibodyantigen complexes
- Sallusto F., Uguccioni M. (2012) Cell migration in tumorigenesis and metastasis
- Uguccioni M. (2012) TIMER - TargetIng novel MEchanisms of Resolution in inflammation
- Lanzavecchia A., Sallusto F., Uguccioni M. (2011) ADITEC - Advanced Immunization Technologies
- Sallusto F. (2011) IDAMS - International Research Consortium on Dengue Risk Assessment, Management and Surveillance
- Sallusto F. (2011) Cell Migration
- Varani L. (2011) RADAR - Rationally Designed Aquatic Receptors integrated in label-free biosensor platforms for remote surveillance of toxins and polluants
- Lanzavecchia A., Catapano C., Thelen M., Uguccioni M., Varani L. (2010) Analysis of the human immune response using high-throughput cellular screening
- Lanzavecchia A. (2010) IMMUNExplore - New approaches to analyze and exploit the human B and T cell response against viruses
- Sallusto F. (2010) Effector and memory T cell subsets in man and mouse
- Grassi F. (2010) i-IronIC - Implantable/Wearable System for on-line Monitoring of Human Metabolic Conditions
- Sallusto F. (2010) NEWTBVAC - Discovery and preclinical development of new generation tuberculosis vaccines
- Grassi F. (2010) Innovative enabling micro-nano-bio-technologies for implantable systems in molecular medicine and personalized therapy
- Uguccioni M. (2009) MD - THIV - Migration and differentiation of Th17 cells in HIV/SIV infection
- Lanzavecchia A. (2009) The role of innate receptors in dendritic cell and B lymphocyte activation
- Molinari M. (2009) Neural Plasticity and Repair
- Grassi F. (2009) Purinergic signaling in T cell physiology
- Varani L. (2009) Prediction and characterization of antibody-protein interactions in Dengue virus
- Monticelli S. (2009) Role of microRNAs in the development and function of cells of the immune system
- Molinari M. (2009) Protein folding, quality control and degradation in the endoplasmic reticulum: Assessing the function of ER-resident molecular chaperones and folding factors
- Lanzavecchia A. (2008) IMECS - Identification of mechanisms correlating with susceptibility for avian influenza
- Lanzavecchia A., Sallusto F. (2008) PEMPHIGUS - From autoimmunity to disease
- Lanzavecchia A. (2008) Identifying immunological mechanisms of protection for influenza vaccines
- Uguccioni M. (2008) Impact of Multiple Chemokine Expression in Human Disease
- Thelen M., Grassi F., Molinari M., Uguccioni M. (2007) Fast laser scanning confocal microscope for real-time investigation of subcellular immunological and cell biological processes
- (2007) Regulation of dendritic cell development from hematopoietic stem and progenitor cells
- Sallusto F. (2007) Memory T cell subsets in man and mouse: identification, characterization and function
- Grassi F. (2007) Signaling microdomains in T cell development
- Lanzavecchia A. (2007) HUMALMAB - Human monoclonal antibodies as tools in malaria reserach and therapy
- (2006) TRIM5 and Innate Resistance to HIV-1
- Grassi F., Sallusto F. (2006) Calcium Signalling in the regulation of the T cell response/calcium imaging unit
- Thelen M. (2006) Chemokine receptors and signal transduction pathways in leukocytes
- Lanzavecchia A. (2006) The role of innate receptors in dendritic cell and B lymphocyte activation
- Lanzavecchia A., Sallusto F. (2006) INTEGRAMM - International graduate programme in molecular medicine
- (2006) Regulation of adaptive immune responses by NK cells
- Molinari M. (2006) Protein folding, quality control and degradation in the endoplasmic reticulum: Assessing the function of ER-resident molecular chaperones and folding factors
- Uguccioni M. (2006) DEC-VAC - Development of a Dendritic Cell-targeted Vaccine against AIDS
- Sallusto F., Thelen M., Uguccioni M. (2005) INNOCHEM - Innovative Chemokine-based Therapeutic Strategies for Autoimmunity and Chronic Inflammation
- Sallusto F. (2005) SENS-IT-IV - Novel testing strategies for in vitro assessment of allergens
- Lanzavecchia A., Sallusto F., Uguccioni M. (2005) DC-THERA - Dendritic cells for novel immuotherapies
- Lanzavecchia A., Grassi F., Sallusto F. (2005) MUGEN - Integrated functional Genomics in mutant mouse models as tools to investigate the complexity of Human Immunological Disease
- Uguccioni M. (2005) TIP-VAC - Explaining and Improving Efficacy of targeted Immunodeficiency Virus-like Particles against AIDS
- Grassi F. (2004) Molecular requirements and subcellular routing of signals in pre-T cell development and leukemogenesis
- Lanzavecchia A. (2004) SARSVAC - Immunoprevention and immunotherapy of SARS infection
- Lanzavecchia A., Sallusto F., Thelen M., Uguccioni M. (2004) MAIN - Targeting cell migration in chronic inflammation
- Sallusto F. (2004) TB-VAC - An Integrated Project for New Vaccines against Tuberculosis
- Lanzavecchia A. (2003) MUVAPRED - Mucosal Vaccines for Poverty Related Diseases
- (2003) Development and characterization of a mouse model to study the human hematopoietic and immune system in vivo
- Sallusto F. (2003) Dissection of human memory T lymphocytes
- Thelen M. (2003) Chemokine receptor activated signal transduction pathways
- Thelen M. (2003) Chemokine receptor activated signal transduction pathways.
- Uguccioni M. (2002) MUVADEN - Mucosal Vaccines Against Human and Simian Immunodeficiency Viruses Based on Dendritic Cells
- Molinari M. (2002) Protein folding and quality control in the endoplasmatic reticulum. Assessing the function of ER-resident molecular cheperones and folding factors
- (2002) Mechanisms regulating activation and termination of Nuclear Factor kappa B (NF-kB) - dependent transcriptional responses
- Sallusto F. (2001) MEMOVAX - Immunological memory and vaccination
- Thelen M. (2001) Chemokine receptor mediated signal transduction
- Lanzavecchia A. (2001) Dendritic cells: origin, maturation and impact on T cell responses
- Thelen M. (2000) Molecular mechanisms of signal transduction
- Uguccioni M. (2000) DETEC - SIV/HIV vaccines - detecting efficacy and explaining inefficacy
