Paolo Paganetti was born and raised in Locarno, Ticino. He has studied biochemistry and received in 1989 the degree of Doctor in Natural Sciences at the Federal Institute of Technology in Zurich (ETHZ). He was postdoctoral fellow at the Brain Research Institute, University of Zurich and at the Howard Hughes Medical Institute and Department of Molecular and Cellular Physiology, Stanford University, California. In 1991, he became laboratory head at the Sandoz Research Institute Bern, and then moved to Basel in 1997 first at Novartis Pharma AG and then at the Novartis Institutes for Biomedical Research where he occupied positions of increasing responsibility and was nominated director in 2010. After a three-year experience at AC Immune SA in Lausanne, in he came back to Ticino and joined the NeuroCenter of Southern Switzerland of the Ente Ospedaliero Cantonale as the Head of the Laboratory for Biomedical Neurosciences and Leader of the Neurodegeneration Research Group. His research interest focus on the cell biology of disease in particular with regards to the molecular and cellular mechanisms involved in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, frontotemporal dementia and ametropic lateral sclerosis. He is a dedicated mentor of young scientists interested in a career as researchers in biomedicine. His laboratory has hosted dozens of master students, PhD students and postdoctoral fellows.