Antibodies against Dengue Virus: which ones are effective against this neglected disease and why? Searching for correlations between structural, dynamics and immunological properties of antibodyantigen complexes

The complementary expertise of the participants will be applied to Dengue virus, a neglected disease causing 500,000 hospitalizations and 20,000 deaths per year. The aim is to compare the binding of antibodies that recognizes the surface protein of the four Dengue serotypes, searching for correlations between immunological, structural, dynamics and binding properties, to further the understanding of antibody/antigen interaction as well as a basis for drug design and improved vaccine strategies.