Marginal zone lymphomas
Informazioni aggiuntive
Autori
Zucca E.,
Rossi D.,
Bertoni F.
Tipo
Articolo pubblicato in rivista scientifica
Anno
2023
Lingua
Inglese
Sommario
The three main types of marginal zone lymphoma (MZL), recognized by the current lymphoma classifications are the extranodal MZL of mucosa‐associated lymphoid tissue, the splenic MZL, and the nodal MZL. They share some karyotype lesions (trisomies of chromosomes 3 and 18, deletions at 6q23), and alterations of the nuclear factor kappa B (NFkB) pathway are also common in all of them. However, they differ in the presence of recurrent translocations, mutations affecting the Notch signaling pathway (NOTCH2 and less commonly NOTCH1), the transcription factors Kruppel‐like factor 2 (KLF2) or the receptor‐type protein tyrosine phosphatase delta (PTPRD). This review summarizes the most recent and significant advances in our understanding of the epidemiology, genetics, and biology of MZLs and outlines the current principles of the standard management of MZL at different anatomic sites.
Parole chiave
Extranodal MZL of MALT type, Marginal zone lymphoma, Nodal MZL, Splenic MZL
Periodico
Hematological Oncology
Volume
41
Numero ( Mese )
S1
Pagine (o numero dell’articolo)
88
DOI
Diffusione
Licenza
CC BY-NC-ND
Visibilità
Pubblico
Status open access
Hybrid
