Is computed-tomography-based body composition a reliable predictor of chemotherapy-related toxicity in pancreatic cancer patients?
Informazioni aggiuntive
Autori
Cefalì M.,
Scala I.,
Pavone G.,
Helbling D.,
Hussung S.,
Fritsch R.,
Reiner C.,
Stocker S.,
Koeberle D.,
Kissling M.,
Chianca V.,
Del Grande F.,
De Dosso S.,
Rizzo S. M. R.
Tipo
Articolo pubblicato in rivista scientifica
Anno
2023
Lingua
Inglese
Sommario
Background: Malnutrition, loss of weight and of skeletal muscle mass are frequent in pancreatic cancer patients, a majority of which will undergo chemotherapy over the course of their disease. Available data suggest a negative prognostic role of these changes in body composition on disease outcomes; however, it is unclear whether tolerance to chemotherapeutic treatment is similarly and/or negatively affected. We aimed to explore this association by retrospectively assessing changes in body composition and chemotherapy-related toxicity in a cohort of advanced pancreatic cancer patients. Methods: Body composition was evaluated through clinical parameters and through radiological assessment of muscle mass, skeletal muscle area, skeletal muscle index and skeletal muscle density; and an assessment of fat distribution by subcutaneous adipose tissue and visceral adipose tissue. We performed descriptive statistics, pre/post chemotherapy comparisons and uni- and multivariate analyses to assess the relation between changes in body composition and toxicity. Results: Toxicity risk increased with an increase of skeletal muscle index (OR: 1.03) and body mass index (OR: 1.07), whereas it decreased with an increase in skeletal muscle density (OR: 0.96). Multivariate analyses confirmed a reduction in the risk of toxicity only with an increase in skeletal muscle density (OR: 0.96). Conclusions: This study suggests that the retrospective analysis of changes in body composition is unlikely to be useful to predict toxicity to gemcitabine—nab-paclitaxel.
Parole chiave
Body composition, Pancreatic cancer, Toxicity
Periodico
Cancers
Volume
15
Numero ( Mese )
17
Pagine (o numero dell’articolo)
4398
Diffusione
Licenza
CC BY
Visibilità
Pubblico
Status open access
Gold
