The P2X7 receptor in autoimmunity
Informazioni aggiuntive
Autori
Grassi F.,
Salina G.
Tipo
Articolo pubblicato in rivista scientifica
Anno
2023
Lingua
Inglese
Sommario
The P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel that, upon intense stimulation, can progress to the opening of a pore permeable to molecules up to 900 Da. Apart from its broad expression in cells of the innate and adaptive immune systems, it is expressed in multiple cell types in different tissues. The dual gating property of P2X7R is instrumental in determining cellular responses, which depend on the expression level of the receptor, timing of stimulation, and microenvironmental cues, thus often complicating the interpretation of experimental data in comprehensive settings. Here we review the existing literature on P2X7R activity in autoimmunity, pinpointing the different functions in cells involved in the immunopathological processes that can make it difficult to model as a druggable target.
Parole chiave
Purinergic signaling, Autoimmunity, Autoantibodies, T cells
Periodico
International Journal of Molecular Sciences
Volume
24
Numero ( Mese )
18
Pagine (o numero dell’articolo)
14116
Diffusione
Licenza
CC BY
Visibilità
Pubblico
Status open access
Gold
