The effect of repetitive transcranial magnetic stimulation treatment on plasma BDNF concentration and executive functions in Parkinson’s disease
a theoretical translational medicine approach
Additional information
Authors
Riccitelli G. C.,
Gironi R.,
Melli G.,
Kaelin-Lang A.
Type
Journal Article
Year
2025
Language
English
Abstract
Parkinson’s disease (PD) neuropathology is marked by the selective loss of dopaminergic neurons in the substantia nigra pars compacta, accompanied by the widespread involvement of central and peripheral structures. Brain-derived neurotrophic factor (BDNF), a neurotrophin crucial for the survival of dopaminergic neurons, plays a pivotal role in neuronal and glial development, neuroprotection, and the modulation of synaptic plasticity. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique, enhances neurotransmitter release, trans-synaptic efficacy, signaling pathways, gene transcription, neuroplasticity, and neurotrophism. Evidence supports that high-frequency rTMS increases BDNF expression and improves task-specific cognitive deficits in PD patients. This article outlines a detailed protocol to investigate whether rTMS targeting the dorsolateral prefrontal cortex bilaterally induces changes in plasma BDNF levels, the plasma-derived exosomal BDNF concentration, and executive functions in individuals with PD. Identifying non-invasive interventions that effectively modulate the neurobiological mechanisms underlying cognitive and behavioral functions is critical for addressing cognitive impairments and mitigating disease progression in the PD population. This study aims to advance translational research by identifying biomarkers and developing therapeutic strategies for future applications in neurodegenerative diseases.
Keywords
Neuroprotection, Biomarker validation, Translational medicine, Non-invasive therapy
Journal
International Journal of Molecular Sciences
Volume
26
Number ( Month )
3
Pages (or article number)
1205
Diffusion
License
CC BY
Visibility
Public
Status open access
Gold
