Correlation between blood monocytes and CSF tau in Alzheimer’s disease
the effect of gender and cognitive decline
Additional information
Authors
Cimiotti C. G. V.,
Paganetti P.,
Rossi S.,
Soldini E.,
Sacco L.
Type
Journal Article
Year
2023
Language
English
Abstract
Neuroinflammation is one of the main mechanisms contributing to the pathogenesis of Alzheimer’s disease (AD), although its key role and the immune cells involved have not yet been identified. Blood monocytes appear to play a role in the clearance of AD-related amyloid-β (Aβ) and tau protein. This retrospective study evaluated a possible correlation between blood monocytes; the concentrations of Aβ, total tau (t-Tau), and phosphorylated tau (p-Tau) in the cerebrospinal fluid (CSF); and cognitive decline assessed according to the Montreal Cognitive Assessment (MoCA). We collected data from 33 patients with AD or mild cognitive impairment (MCI) due to AD (15 men and 18 women) and found, along with a significant reduction in the concentration of blood monocytes in women (p-value = 0.083), significant correlations between the number of blood monocytes and the concentration of t-Tau in CSF (p-value = 0.045) and between blood monocytes and MoCA score (p-value = 0.037). These results confirm the role of blood monocytes in the pathogenesis of AD, provide further evidence of a gender difference in the neuroinflammatory process underlying AD, and show that blood monocyte count may reflect the cognitive impairment of AD patients.
Keywords
Patients, Monocytes, Tau, Cerebrospinal fluid, MoCA, Gender difference, Cognitive decline, Alzheimer’s disease pathogenesis, Diagnostics
Journal
NeuroSci
Volume
4
Number ( Month )
4
Pages (or article number)
319-330
Diffusion
License
CC BY
Visibility
Public
Status open access
Gold
