This course introduces the basic concepts of epidemiology and biostatistics as applied to public health problems, clinical issues and areas of health services such as genetic counseling. Emphasis is placed on the principles and methods of epidemiologic investigation, appropriate summaries and displays of data, and the use of classical statistical approaches to describe the health of populations. Topics include the use of conditional probability theory in biostatistics including screening and diagnostic tests, ROC curve; how to design an experiment in public health frameworks. Various epidemiologic study designs for investigating associations between risk factors and disease outcomes are also introduced, culminating with criteria for causal inferences. Applications of epidemiological issues in SPSS are part of the course.