Lean Six Sigma is a methodology that relies on a collaborative team effort to improve performance that not only reduces process defects and waste, but also provides a framework for overall organizational culture change. Lean traditionally focuses on the elimination of the eight kinds of waste while Six Sigma aims to reduce process variation enabling a virtuous cycle of iterative improvements towards the goal of continuous flow. Lean Six Sigma, as a industry-agnostic methodology, provides tools and techniques that are applied in aerospace, electronics, telecom, banking and financial services, IT, HR, marketing, and many more industries. The course will discuss and present Lean Six Sigma quality management tools and principles and their organizational implication more than the statistical formulas and their application. For the few statistical application presented will be used R and R Studio: the preferred computing environment for a large part of the statistical community.