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DEC-VAC - Development of a Dendritic Cell-targeted Vaccine against AIDS

People

 

Uguccioni M.

(Responsible)

Abstract

With support from two successive, framework V, EU sponsored consortia, we have developed an in vivo targeting approach for dendritic cells (DC) applicable to protein vaccines, DNA vaccines, and viral vector vaccines. Antibodies directed against the DC-specific, endocytic receptor DEC-205 allowed efficient uptake and presentation of antigens coupled to the antibodies by the targeted DCs. Providing a costimulatory signal resulted in potent antiviral immune responses. Given the urgent need for an HIV vaccine, the potential of this innovative vaccine approach should be evaluated as quickly as possible. Therefore, the aims of the current application of the consortium are to determine the efficacy of DEC-205-targeted protein-, DNA-, and viral vector vaccines in animal models and to understand requirements for and mechanisms of protection.

Additional information

Acronym
DEC-VAC
Start date
01.01.2006
End date
01.01.2011
Duration
60 Months
Funding sources
Status
Ended
Category
European and International Programmes / Framework Programme 6