NLRC5
back to innate immunity
Informazioni aggiuntive
Tipo
Articolo pubblicato in rivista scientifica
Anno
2024
Lingua
Inglese
Sommario
NLRC5 is a transcriptional regulator of genes governing T cell responses. Most characterized NLRs are instead innate immune sensors forming complexes leading to pyroptosis. Raising exciting questions, Sundaram and colleagues now demonstrate that NLRC5 forms large complexes and causes PANoptosis (immunogenic cell death), in response to heme in inflammatory contexts.
Periodico
Trends in immunology
Diffusione
Licenza
CC BY-NC-ND
Visibilità
Pubblico
Status open access
Hybrid
