NLRC5
back to innate immunity
Additional information
Type
Journal Article
Year
2024
Language
English
Abstract
NLRC5 is a transcriptional regulator of genes governing T cell responses. Most characterized NLRs are instead innate immune sensors forming complexes leading to pyroptosis. Raising exciting questions, Sundaram and colleagues now demonstrate that NLRC5 forms large complexes and causes PANoptosis (immunogenic cell death), in response to heme in inflammatory contexts.
Journal
Trends in immunology
Diffusion
License
CC BY-NC-ND
Visibility
Public
Status open access
Hybrid
